am a medicinal chemist, but also program leader for an early stage phenotypic
drug discovery project, at a major pharmaceutical company.
I joined the company with an MChem degree from Bristol University. I have since completed my PhD due to an innovative scheme set up between the company and the University of Strathclyde. This allowed me to complete my PhD on my day-to-day research.
I have A-levels in Biology, Chemistry and Maths.
I first started, my role was ~90% lab work, but in the 14 years I have worked
here, this has gradually reduced as other roles have grown.
~10 years into my role, 40 to 50% of my time was spent in the laboratory synthesising chemical compounds. The rest was spent in discussions with colleagues about our work, analysing biological data, designing molecules to make and considering what direction our work should go in. I used computational modelling, X-ray crystallography and data analysis to design molecules that might become new medicines.
I now spend my time between meetings (group or individual) and working at my computer.
As a medicinal chemist, I started my career working predominantly in the laboratory, synthesising intermediates and novel chemical compounds. Soon after joining I was asked to supervise an industrial placement student, since then I have gained management experience through supervising some members of permanent staff. I was also a supervisor for a CASE PhD student who was being sponsored by my company – she spent 3 months in our lab. Supervising her gave me the opportunity to learn about a different type of chemistry to the work I normally do.
As my career progressed I became more
involved in the interpretation of biological, physicochemical and protein
structure data to enable the design of new ligands. From there, I moved on to a program
leadership role, where I am still heavily involved in science, but also working
closely with a matrix team of individuals from different disciplines to define
When I was applying for industrial placements I decided that I would prefer to work in the pharmaceutical industry as I wanted to help people by creating improved treatments for disease.
During my year’s placement I decided that this was definitely what I wanted to do. Most people here are motivated by wanting to help cure disease and improve patients’ quality of life.
Some of the day is spent working on my own, but it is an essential part of my job to work with others, particularly in the program leader role where I am connecting with colleagues in other areas of the business.
I work closely with colleagues – both other chemists in my team and a wider group of scientists including biologists and clinical scientists who are all working on treatments for the same disease area. This programme team could include pharmacologists, toxicologists, drug metabolism and pharmacokinetics (DMPK) scientists, clinicians and sometimes statisticians and other specialists.
Great. We have plenty of opportunity for informal
socialisation at coffee break or lunch and there are also evening socials
I am very proud to have been directly involved in three programs which have reached clinical trials, two of which are still progressing. I have also had opportunities to present my work at conferences, through poster sessions and oral presentations.
Recently, I was delighted to be recognised externally for my contributions to the industry with the “RSC’s Young
Industrialist of the Year Award, 2015”.
An MChem 4 year degree with an industrial placement is still a very good qualification to have if you want a job in the pharmaceutical industry.
Some people have a PhD or have been a postdoc before they come to work here. As I already mentioned I completed my PhD whilst working. I don’t think there is one “right” path.
It is pretty good. We socialise as a team, both informally and sometimes we arrange to go out to lunch together. There are also organised Christmas and summer social events.
am currently really enjoying the program leadership role, but there are plenty
of options open to me. I could consider
taking more of a line management role, or trying a secondment in another area. It’s really up to me to decide!
Communication is very important when you are working as part of a project team. You need to be able to explain your ideas clearly to other scientists. Good teamworking is obviously important as are good organisational skills.
If you are offered a placement as part of your degree you should definitely take it. It is a fantastic opportunity to find out what a job is like before you have to make a decision on what to apply for after your degree. And, as in my case, you may get a job in the company you did the placement in.
The level of responsibility I have has gradually increased with time. I am now accountable for ensuring the success of the project and delivering new lead compounds for clinical testing.